Hippocampal Avoidance Prophylactic Cranial Irradiation: A New Standard of Care?
نویسندگان
چکیده
منابع مشابه
Models support prophylactic cranial irradiation.
In this issue of the Journal of Clinical Oncology, Lee et al present a rather unique and useful statistical interpretation of the waxing question of prophylactic cranial irradiation (PCI) for patients with small-cell lung cancer (SCLC). The concept of PCI for SCLC has its origins in the comparison of the behavior of this disease with childhood leukemia, a disease that is essentially systemic in...
متن کاملProphylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.
BACKGROUND Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. METHODS We analyzed individual data on 987 patients with small-c...
متن کاملProphylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer.
Small-cell lung cancer (SCLC) has a high predilection for metastasizing to the brain after chemotherapy. This has been blamed on the blood-brain barrier, which prevents chemotherapy from penetrating into the brain, thus creating a sanctuary site. It has been estimated that up to three quarters of patients with SCLC will eventually develop brain metastases. This led investigators to administer p...
متن کاملOutlook following "somnolence syndrome" after prophylactic cranial irradiation.
Outlook following "somnolence syndrome" after prophylactic cranial irradiation The "somnolence syndrome" consists of drowsiness, lethargy, anorexia, and irritability occuring in about 600% of children six weeks after prophylactic irradiation of the central nervous system in acute leukaemia or non-Hodgkin's lymphoma.1 It is associated with electroencephalographic (EEG) abnormalities.1 We have st...
متن کاملProphylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer.
abtract Purpose Extensive-stage small-cell lung cancer (esSCLC) is an incurable disease and represents a therapeutic challenge because of its poor prognosis. Studies in prophylactic cranial irradiation (PCI) in esSCLC have shown a decreased incidence of symptomatic brain metastases in patients who respond to systemic chemotherapy. However, its effect on overall survival is debatable. We evaluat...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2021
ISSN: ['1527-7755', '0732-183X']
DOI: https://doi.org/10.1200/jco.21.01632